Michael J. Fox
Stuart Little (voice)
Brian Doyle-Murray
Cousin Edgar
Jeffrey Jones
Uncle Crenshaw
Jon Polito
Officer Sherman
Kimmy Robertson
Race Spectator
Jennifer Tilly
Mrs. Stout (voice)
Chazz Palminteri
Smokey (voice)
Bruno Kirby
Mr. Stout (voice)
Julia Sweeney
Mrs. Keeper
Dabney Coleman
Dr. Beechwood
Harold Gould
Grandpa Spencer
Geena Davis
Mrs. Little
Steve Zahn
Monty (voice)
Connie Ray
Aunt Tina
Taylor Negron
Salesman
Hugh Laurie
Mr. Little
David Alan Grier
Red (voice)
Estelle Getty
Grandma Estelle
Miles Marsico
Anton
Jonathan Lipnicki
George Little
Patrick Thomas O'Brien
Uncle Stretch
Nathan Lane
Snowbell (voice)
Allyce Beasley
Aunt Beatrice
Joe Bays
Race Starter
Stan Freberg
Race Announcer (voice)
Jim Doughan
Lucky / Officer Allen (voice)
Joshua Paule
New Yorker (uncredited)