Allison Janney
Madge Nelson (voice)
Reese Witherspoon
Rosita (voice)
Danny DeVito
The Lorax (voice)
Michael Keaton
Walter Nelson (voice)
Steve Carell
Gru (voice) (uncredited)
John C. Reilly
Eddie (voice)
Patton Oswalt
Max (voice)
Tara Strong
Garry's Mom / Neanderthal Baby / Binky (voice)
Gilbert Gottfried
Infestor (voice)
Nick Offerman
Norman (voice)
Ed Helms
Once-ler (voice)
Laraine Newman
Eddie's Mom (voice)
Garth Jennings
Miss Crawly (voice)
Kevin Hart
Snowball (voice)
Katy Mixon
Tina (voice)
Carlos Alazraqui
Guard / Additional Voices (voice)
Michael Beattie
Walter Junior (voice)
Bill Farmer
Additional Voices (voice)
Jess Harnell
Additional Voices (voice)
Mona Marshall
Additional Voices (voice)
Pierre Coffin
Minions (voice)
Chris Renaud
Minions / Pipsqueak / Neanderthal Dad / The Animals (voice)
Nick Kroll
Gunter (voice)
Jenny Slate
Gidget (voice)
Bobby Moynihan
Mel (voice)
Matt Kawczynski
Security Guard (voice)
Brad Morris
Garry Wishmann (voice)
Dave Rosenbaum
Dave (voice)
Brian T. Delaney
Hal (voice)
Jody Gelb
Barb / Ella (voice)
Caspar Jennings
Piglet (voice)
Eric Osmond
Additional Voices (voice)