Maggie Gyllenhaal
Ana Pascal
Tom Hulce
Dr. Cayly
Dustin Hoffman
Professor Jules Hilbert
Emma Thompson
Karen Eiffel
Linda Hunt
Dr. Mittag-Leffler
Queen Latifah
Penny Escher
Cheryl Lynn Bruce
Head ER Nurse
Will Ferrell
Harold Crick
Tony Hale
Dave
Christian Stolte
Young Boy's Father
Denise Hughes
Kronecker Bus Driver
Peggy Roeder
Polish Woman
Nathan Adloff
Bakery Patron (uncredited)
Kristin Chenoweth
Book Channel Host
Bruce Jarchow
Commuter
Danny McCarthy
Demolition Crew #1
Ora Jones
Banneker Press Receptionist
Tab Baker
Demolition Crew #2
Andrew Rothenberg
Doctor Mercator
Linara Washington
Bakery Employee #2
Bob Papenbrook
Animal Footage Voice Over (voice)
T.J. Jagodowski
IRS Co-Worker #4
John Mohrlein
Man with Hose
Tim Krueger
Business Man (uncredited)
Peter Grosz
IRS Co-Worker #5
Tonray Ho
IRS Co-Worker #6
Danny Rhodes
Bakery Employee #1
Will Clinger
Accident Witness
Celeste Pechous
ER Nurse #2
Frank Caeti
Accident Witness
Jarrett Sleeper
Bakery Customer #4
Sia A. Moody
Nurse #3 (uncredited)
Keith Kupferer
Demolition Foreman
Eli Goodman
Augustus Chatman (uncredited)
John M. Watson Sr.
TV Author
Bradley Mott
Large Man on Bus
Guy Massey
IRS Co-Worker #2
Bryan Kelly
ER Orderly
Helen Young
Bakery Customer #1
Whitney Sneed
ER Nurse #1
Ray Kurut
ER Doctor #2
Mike McColl
Animal Footage Voice Over (voice)