Sally Field
Aunt May
Vincent Laresca
Construction Worker
C. Thomas Howell
Jack's Father
Denis Leary
Captain Stacy
Embeth Davidtz
Mary Parker
Rhys Ifans
Dr. Curt Connors / The Lizard
Stan Lee
School Librarian
Martin Sheen
Uncle Ben
Michael Massee
Gustav Fiers
Jay Caputo
Subway Guy
Keith Campbell
Car Thief
Michael Papajohn
Alfie (uncredited)
Andrew Garfield
Peter Parker / Spider-Man
Emma Stone
Gwen Stacy
Campbell Scott
Richard Parker
John Burke
Newscaster (News Chopper)
Hannah Marks
Missy Kallenback
Skyler Gisondo
Howard Stacy
Ethan Cohn
Lab Technician (uncredited)
Jennifer Lyons
Second Girl (Subway)
Steve DeCastro
Car Thief Cop
Tia Texada
Sheila (Subway)
Irrfan Khan
Rajit Ratha
Kevin McCorkle
Mr. Cramer
Danielle Burgio
Nicky's Girlfriend
Jill Flint
Receptionist
Barbara Eve Harris
Miss Ritter
Amanda MacDonald
Goth Girl (uncredited)
Kelsey Asbille
Sally Avril
Chris Zylka
Flash Thompson
Max Charles
Peter Parker (Age 4)
Jacob Rodier
Simon Stacy
James Chen
Police Officer
Alexander Bedria
Officer (SWAT)
Miles Elliot
Billy Connors (uncredited)
Leif Gantvoort
Cash Register Thief
Mark Daugherty
OsCorp Intern
Amber Stevens West
Ariel
Terry Bozeman
Principal
Andy Pessoa
Gordon
Ty Upshaw
Police Officer with Sketch
Jake Keiffer
Jack
Andy Gladbach
Physics Nerd
Ring Hendricks-Tellefsen
Physics Nerd
Tom Waite
Nicky
Max Bogner
Scientist (uncredited)
Charlie DePew
Philip Stacy
Damien Lemon
Taxi Driver
Milton González
Rodrigo Guevara
Miranda LaDawn Hill
Cheerleader (uncredited)
Maury Morgan
Tina (uncredited)