Bruce Willis
Spike (voice)
Nancy Cartwright
Chuckie Finster (voice)
Flea
Donnie Thornberry (voice)
Tim Curry
Nigel Thornberry (voice)
Elizabeth Daily
Tommy Pickles (voice)
Tara Strong
Dil Pickles (voice)
Michael Bell
Drew Pickles / Charles 'Chaz' Finster, Sr. (voice)
Danielle Harris
Debbie Thornberry (voice)
Lacey Chabert
Eliza Thornberry (voice)
Ethan Phillips
Toa (voice)
Tress MacNeille
Charlotte Pickles (voice)
Cree Summer
Susie Carmichael (voice)
Kath Soucie
Phil DeVille / Lil DeVille / Betty DeVille (voice)
Phil Proctor
Howard DeVille (voice)
Jack Riley
Stuart 'Stu' Pickles (voice)
Tony Jay
Dr. Lipschitz (voice)
Tom Kane
Darwin (voice)
Cheryl Chase
Angelica Pickels (voice)
Dionne Quan
Kimi Watanabe-Finster (voice)
Joe Alaskey
Lou Pickles (voice)
Julia Kato
Kira Watanabe-Finster (voice)
Melanie Chartoff
Didi Pickles (voice)
Chrissie Hynde
Siri (voice)
Jodi Carlisle
Marianne Thornberry (voice)