Uma Thurman
Sissy Hankshaw
Sean Young
Marie Barth
Edward James Olmos
Musician at Barbecue (uncredited)
Crispin Glover
Howard Barth
Udo Kier
Commercial Director
Angie Dickinson
Miss Adrian
John Hurt
The Countess
Keanu Reeves
Julian Gitche
Grace Zabriskie
Mrs. Hankshaw
William S. Burroughs
Self
Ken Kesey
Sissy's Daddy
Lin Shaye
Rubber Rose Maid
Buck Henry
Dr. Dreyfus
Roger Bowen
Naturalist (uncredited)
Carol Kane
Carla
Lorraine Bracco
Delores Del Ruby
Scott Patrick Green
Pilgrim Man
Pat Morita
The Chink
Ed Begley Jr.
Rupert
Roseanne Barr
Madame Zoe
Heather Graham
Cowgirl Heather
Rain Phoenix
Bonanza Jellybean
Tom Robbins
Narrator (voice)
Chel White
Brain Surgeon
Ken Babbs
Sissy's Uncle
Eric Hull
White House Undersecretary
Greg McMickle
FBI Agent
Victoria Williams
Cowgirl Debbie
Allen Arnold
Lionel
Tom Peterson
Crewman