Callum Keith Rennie
Asher Talos
James Remar
Ray Cumberland
Parker Posey
Danica Talos
John Michael Higgins
Dr. Edgar Vance
Wesley Snipes
Eric Brooks / Blade
Kris Kristofferson
Abraham Whistler
Ryan Reynolds
Hannibal King
Jessica Biel
Abigail Whistler
Dominic Purcell
Dracula / Drake
Eric Bogosian
Bentley Tittle
Natasha Lyonne
Sommerfield
Patton Oswalt
Hedges
Françoise Yip
Virago
Brian Steele
Drake Creature (uncredited)
Christopher Heyerdahl
Caulder
Clay Cullen
Stone
Birkett Turton
Dingo
Paul Michael Lévesque
Jarko Grimwood
Mark Berry
Chief Martin Vreede
Michael Anthony Rawlins
Wilson Hale
Paul Anthony
Wolfe
Erica Cerra
Goth Vixen Wannabe