Uma Thurman
The Bride / Beatrix Kiddo (Black Mamba) / Mommy
Lucy Liu
O-Ren Ishii (Cottonmouth)
David Carradine
Bill (Snake Charmer)
Michael Madsen
Budd (Sidewinder)
Daryl Hannah
Elle Driver (California Mountain Snake)
Samuel L. Jackson
Rufus
Michael Bowen
Buck
Vivica A. Fox
Vernita Green (Copperhead)
Michael Parks
Earl McGraw / Esteban Vihaio
Sonny Chiba
Hattori Hanzo
Chiaki Kuriyama
Gogo Yubari
Julie Dreyfus
Sofie Fatale
Jun Kunimura
Boss Tanaka
Kazuki Kitamura
Crazy 88 #2 / Boss Koji
Akaji Maro
Boss Ozawah
Ambrosia Kelley
Nikki Bell
Sid Haig
Jay (Bartender)
Christopher Allen Nelson
Tommy Plympton
Perla Haney-Jardine
B.B.
Shun Sugata
Boss Benta
Bo Svenson
Reverend Harmony
Ai Maeda
O-Ren (anime sequence) (voice)
Larry Bishop
Larry Gomez
Jonathan Loughran
Trucker
Sakichi Sato
Charlie Brown
Yoshiyuki Morishita
Tokyo Businessman
James Parks
Edgar McGraw
Issey Takahashi
Crazy 88 #4
Jeannie Epper
Mrs. Harmony
Yoji Tanaka
Crazy 88 #3
Sō Yamanaka
Crazy 88 #5
Hikaru Midorikawa
Pretty Riki (anime sequence) (voice)
Kenji Ohba
Bald Guy
Clark Middleton
Ernie (uncredited)
Shu Lan Tuan
Okinawa Airline Ticket Agent
Gordon Liu Chia-hui
Johnny Mo / Pai Mei
Yuki Kazamatsuri
Proprietor
Laura Cayouette
Rocket
Shana Stein
Erica (uncredited)
Caitlin Keats
Janeen (uncredited)
Helen Kim
Karen
Naomi Kusumi
Boss Matsumoto (anime sequence) (voice)
Juri Manase
Crazy 88 #6 (Girl)
Claire Smithies
Clarita
Goro Daimon
Boss Honda
Zhang Jinzhan
Boss Orgami
Tetsuro Shimaguchi
Crazy 88 #1 (Miki)
Hu Xiaohui
Young 88 (Spanked Boy)