Alice Braga
Sol Soria
Michael Rooker
Brian Durlin / Savant
Peter Capaldi
Gaius Grieves / The Thinker
Sylvester Stallone
Nanaue / King Shark (voice)
Idris Elba
Robert DuBois / Bloodsport
Viola Davis
Amanda Waller
Natalia Safran
Kaleidoscope
Dee Bradley Baker
Sebastian (voice)
Juan Diego Botto
Presidente General Silvio Luna
Sean Gunn
Weasel / Calendar Man
Nathan Fillion
Cory Pitzner / T.D.K.
Taika Waititi
Ratcatcher
John Cena
Christopher Smith / Peacemaker
Rey Hernandez
Teniente
Joaquín Cosío
Mayor General Mateo Suarez
Lloyd Kaufman
Dancing La Gatita Bar Patron (uncredited)
David Dastmalchian
Abner Krill / Polka-Dot Man
Stephen Blackehart
Briscoe
Jennifer Holland
Emilia Harcourt
Joel Kinnaman
Colonel Rick Flag
Sergio Carlo
Isabella's Second
Pom Klementieff
La Gatita Amable Dancer (uncredited)
Jai Courtney
George 'Digger' Harkness / Captain Boomerang
Margot Robbie
Harleen Quinzel / Harley Quinn
Steve Agee
John Economos / On-Set King Shark
Gerardo Davila
General Vera
Josh Ventura
Astronaut
Storm Reid
Tyla DuBois
Fernando Martinez
Sliced Dome Soldado
Mikaela Hoover
Camila
Randy Havens
Star-Crossed Man
Terence Rosemore
Crew Chief
Pete Davidson
Richard Hertz / Blackguard
Flula Borg
Gunter Braun / Javelin
Michael Aaron Milligan
Star-Crossed Dude
Andrea Andrade
La Gatita Waitress
Lynne Ashe
Polka-Dot Man's Mom
Giovanni Rodriguez
Texting Torturer
Mayling Ng
Mongal
Maya Le Clark
Young Cleo
Tinashe Kajese
Flo Crawley
J.R. Adduci
Road Block Soldado
Daniela Melchior
Cleo Cazo / Ratcatcher 2
Reinaldo Faberlle
Large Guerrilla
Ray Benitez
Coronel
John Ostrander
Doctor Fitzgibbon
Kenneth Trujillo
Bespectacled Soldado
Diany Rodriguez
Star-Crossed Gal
Victoria Paige Watkins
Tiff (uncredited)
Giovannie Cruz
Isabella
Julio Cesar Ruiz
Milton