Johnny Depp
Rango / Lars (voice)
Alfred Molina
Roadkill (voice)
Gore Verbinski
Sgt Turley / Crevice / Slim / Lupe - Mariachi Violin (voice)
Bill Nighy
Rattlesnake Jake (voice)
Harry Dean Stanton
Balthazar (voice)
Beth Grant
Bonnie (voice)
Ray Winstone
Bad Bill (voice)
John Cothran
Elgin (voice)
Alanna Ubach
Boo / Cletus / Fresca / Miss Daisy (voice)
Ian Abercrombie
Ambrose (voice)
Charles Fleischer
Elbows (voice)
Ned Beatty
Mayor (voice)
Keith Campbell
Sod Buster (voice)
Abigail Breslin
Priscilla (voice)
Stephen Root
Doc / Merrimack / Mr. Snuggles (voice)
Timothy Olyphant
Spirit of the West (voice)
Blake Clark
Buford (voice)
Maile Flanagan
Lucky (voice)
Claudia Black
Angelique (voice)
Lew Temple
Furgus / Hitch (voice)
Ryan Hurst
Jedidiah (voice)
Vincent Kartheiser
Ezekiel / Lasso Rodent (voice)
Isla Fisher
Beans (voice)
Patrika Darbo
Delilah / Maybelle (voice)
Joe Nuñez
Rock-Eye (voice)
Kym Whitley
Melonee (voice)
Gil Birmingham
Wounded Bird (voice)
James Ward Byrkit
Waffles / Gordy / Papa Joad / Cousin Murt / Curlie / Knife Attacker / Rodent Kid (voice)
Hemky Madera
Chorizo (voice)
George DelHoyo
Señor Flan - Mariachi Accordion (voice)
Alex Manugian
Spoons (voice)
Christopher Lee Parson
Hazel / Kinski / Stump / Clinker / Lenny / Boseefus (voice)
Mark 'Crash' McCreery
Parsons (voice)