Grey DeLisle
Mandy (voice)
Henry Gibson
Lord Pain (voice)
Fred Willard
Boogey (voice)
Michael McKean
Kalgoron (voice)
Dee Bradley Baker
Chocolate Cow (voice)
Armin Shimerman
General Skarr (voice)
Phil LaMarr
Mr. Spleen (voice)
Jane Carr
Pud'n (voice)
David L. Lander
Curtis (voice)
Maxwell Atoms
Jeff the Spider (voice)
Richard Steven Horvitz
Billy / Billy's Dad (voice)
Vanessa Marshall
Irwin (voice)
Jennifer Hale
Gladysaur (voice)
Rachael MacFarlane
Mindy / Velma's Mom / Eris (voice)
Kari Wahlgren
Velma Green the Spider Queen (voice)
Chris Cox
Principal Goodvibes (voice)
Greg Eagles
Grim / Sperg (voice)
James Sie
Plain Cow (voice)
Dave Wittenberg
Velma's Dad / Spider #1 (voice)