Elizabeth Perkins
May / Quippy Spider-Person (voice)
Alfred Molina
Doctor Octopus (voice) (archive footage) (uncredited)
Tobey Maguire
Peter Parker / Spider-Man (archive footage) (uncredited)
Denis Leary
Captain Stacy (archive footage) (uncredited)
Kathryn Hahn
Doc Ock (voice)
Jason Schwartzman
Jonathan Ohnn / Spot (voice)
J.K. Simmons
J. Jonah Jameson (voice)
Cliff Robertson
Ben Parker (archive footage) (uncredited)
Josh Keaton
Spectacular Spider-Man (voice)
Peter Sohn
Ganke (voice)
Oscar Isaac
Miguel O'Hara / Spider-Man 2099 (voice)
Rachel Dratch
Ms. Weber (voice)
Andrew Garfield
Peter Parker / Spider-Man (archive footage) (uncredited)
Caitlin McKenna
Additional Voices (voice)
Andy Samberg
Ben Reilly / Scarlet Spider (voice)
Jorma Taccone
Adriano Tumino / '67 (voice)
Richard Miro
Additional Voices (voice)
Shea Whigham
George Stacy (voice)
Andrew Morgado
Additional Voices (voice)
Michelle Ruff
Additional Voices (voice)
Chrystee Pharris
Additional Voices (voice)
David Michie
Additional Voices (voice)
Luisa Leschin
Additional Voices (voice)
Phil Lord
Additional Voices (voice)
Donald Glover
Aaron Davis
Yuri Lowenthal
Insomniac Spider-Man (voice)
Ismail Bashey
Additional Voices (voice)
Hailee Steinfeld
Gwen Stacy / Spider-Woman (voice)
Luna Lauren Velez
Rio Morales (voice)
Rez Kempton
Additional Voices (voice)
Jacqueline Pinol
Additional Voices (voice)
Ziggy Marley
Lenny (voice)
Christopher Miller
Additional Voices (voice)
June Christopher
Additional Voices (voice)
Deepti Gupta
Additional Voices (voice)
Daniel Kaluuya
Hobie Brown / Spider-Punk (voice)
Sanjay Chandani
Additional Voices (voice)
Andrea Navedo
Additional Voices (voice)
Brian Tyree Henry
Jeff Morales (voice)
Jake Johnson
Peter B. Parker / Spider-Man (voice)
Amandla Stenberg
Margo Kess: Spider-Byte (voice)
Lex Lang
Additional Voices (voice)
Shameik Moore
Miles Morales / Spider-Man (voice)
Melissa Sturm
Mary Jane (voice)
Nic Novicki
Lego Spider-Man (voice)
Atsuko Okatsuka
Yuri (voice)
Mahershala Ali
Uncle Aaron (voice)
Jack Quaid
Peter Parker / The Lizard (voice)
Oscar Camacho
Additional Voices (voice)
Karan Soni
Pavitr Prabhakar / Spider-Man India (voice)
Taran Killam
Web-Slinger (voice)
Al Rodrigo
Additional Voices (voice)
Ben Pronsky
Additional Voices (voice)
Greta Lee
LYLA (voice)
Lorraine Velez
Maria (voice)
Jorge R. Gutierrez
Additional Voices (voice)
Amanda Troop
Additional Voices (voice)
Juan Pacheco
Additional Voices (voice)
Kimiko Glenn
Peni Parker (voice) (uncredited)
Ruth Zalduondo
Additional Voices (voice)
Cedric L. Williams
Additional Voices (voice)
Issa Rae
Jessica Drew / Spider-Woman (voice)
Eliyas Qureshi
Additional Voices (voice)
Kimberly Bailey
Additional Voices (voice)
Sitara Attaie
Additional Voices (voice)
Mike Rianda
Additional Voices (voice)
Jharrel Jerome
Miles G. Morales (voice)
Miguel Jiron
Additional Voices (voice)
Michelle Jubilee Gonzalez
Additional Voices (voice)
Juan Pope
Additional Voices (voice)
Post Malone
Brooklyn Bystander (voice) (archive footage) (uncredited)
Sohm Kapila
Additional Voices (voice)
Marabina Jaimes
Additional Voices (voice)
Arthur Ortiz
Additional Voices (voice)
Warren Sroka
Additional Voices (voice)
Shakira Ja'nai Paye
Additional Voices (voice)
Sofia Barclay
Malala Windsor: Spider-UK (voice)
Peggy Lu
Mrs. Chen (archive footage) (uncredited)
Metro Boomin
Metro Spider-Man (voice)
Jaswant Dev Shrestha
Additional Voices (voice)
Ayo Edebiri
Glory (voice)
Dennis Singletary
Additional Voices (voice)
Stan Sellers
Additional Voices (voice)
Jason Linere-White
Additional Voices (voice)
Danielle Perez
Charlotte Webber: Sun-Spider (voice)