David Silverman
Cyclops / Donut Store Clerk (voice)
Tom Hollander
Charles Darwin (voice)
Kelly Hu
News Reporter (voice)
Nick Frost
Captain (voice)
Catherine O'Hara
Alma (voice)
Jon Lovitz
Conch (voice)
Richard Kind
Wally (voice)
Alex Borstein
Mali (voice)
Kevin Michael Richardson
Sled Dogs (voice)
Benedict Wong
Dr. Chung (voice)
Henry Winkler
Jepson (voice)
Maria Bamford
Bo's Mom (voice)
Tom Kenny
Mozart / Sled Dogs (voice)
Ken Jeong
Clarance (voice)
Jim Jefferies
Burnie (voice)
Adam Devine
Ed (voice)
Reggie Watts
Hoss / Ernest Shackleton (voice)
Terry Gross
Bomb (voice)
Julia Chan
Mrs. Sun / Little Girl (voice)
Steve Aoki
Vinny (voice)
Raymond S. Persi
That Guy / Booby (voice)
Rachel Bloom
Op (voice)
Zazie Beetz
Dottie (voice)
Jason Hightower
Narrator / Sled Dogs (voice)