David Wenham
Carl
Robbie Coltrane
Mr. Hyde (voice)
Alun Armstrong
Cardinal Jinette
Elena Anaya
Aleera
Kate Beckinsale
Anna Valerious
Martin Klebba
Dwerger (uncredited)
Hugh Jackman
Van Helsing
Marek Vašut
Villager
Richard Roxburgh
Count Vladislaus Dracula
Kevin J. O'Connor
Igor
Tom Fisher
Top Hat
Samuel West
Dr. Victor Frankenstein
Will Kemp
Velkan
Josie Maran
Marishka
Shuler Hensley
Frankenstein's Monster
Silvia Colloca
Verona
Stephen Fisher
Dr. Jekyll
Ryan James
Villager (uncredited)
Dana Morávková
Barmaid
Kacie Borrowman
Dwerger (uncredited)
Jaroslav Vízner
Gendarme
Zuzana Ďurdinová
Opera Singer