Eddie Murphy
Sherman Klump / Buddy Love / Papa / Mama / Grandma / Ernie
Larry Miller
Dean Richmond
Dave Chappelle
Reggie Warrington
James Coburn
Harlan Hartley
Lisa Boyle
Sexy Girl
Jada Pinkett Smith
Carla Purty
Athena Massey
Sexy Girl
John Prosky
Doctor
Jamal Mixon
Ernie Klump Jr.
John Ales
Jason
Alexia Robinson
Sexy Girl
David Ramsey
Student
Sara Ballantine
Nurse
Steve Monroe
Student
Chaz Lamar Shepherd
Student
Montell Jordan
Montell Jordan
Hamilton von Watts
Health Instructor
Julianne Christie
Sporting Goods Clerk
Roy Werner
Guy in Crowd
Tony Carlin
Host
Mark McPherson
Doctor
Quinn Duffy
Bartender
Patricia Wilson
Dean's Secretary
Doug Williams
Band Leader
Chao Li Chi
Asian Man
Nichole McAuley
Fit Woman
Arthur Tovey
Elderly Man in Alumni Receiving Line (uncredited)
Joe Greco
Security Guard
Michael Rothhaar
Doctor
Nick Kokotakis
Waiter
Ned Luke
Construction Worker (uncredited)