Owen Wilson
Gary Dixon
Eric Stoltz
Dr. Steven Cale
Jonathan Hyde
Warren Westridge
Ice Cube
Danny Rich
Jon Voight
Paul Serone
Danny Trejo
Poacher
Frank Welker
Anaconda (voice) (uncredited)
Jennifer Lopez
Terri Flores
Kari Wuhrer
Denise Kalberg
Vincent Castellanos
Mateo