Johnny Depp
Donnie Brasco / Joseph D. 'Joe' Pistone
Michael Madsen
Dominick 'Sonny Black' Napolitano
James Russo
Paulie
Al Pacino
Benjamin 'Lefty' Ruggiero
Tim Blake Nelson
FBI Technician
Terry Serpico
Strip Club Owner
Val Avery
Santo Trafficante Jr.
Antone Pagán
Prison Guard for Pacino and Depp (uncredited)
Brian Tarantina
Bruno
Zeljko Ivanek
Tim Curley
Zach Grenier
Dr. Berger
Anne Heche
Maggie Pistone
Bruno Kirby
Nicholas 'Nicky' Santora
Paul Giamatti
FBI Technician
Gretchen Mol
Sonny's Girlfriend
Denise Faye
Mob Girlfriend
Gerry Becker
Agent Dean Blandford FBI
Katie Sagona
Daughter
Tony Ray Rossi
Wiseguy
Larry Romano
Tommy
Tony Lip
Philip 'Philly Lucky' Giaccone
Robert Miano
Alphonse 'Sonny Red' Indelicato
Rocco Sisto
Richard 'Richie' Gazzo
Madison Arnold
Jilly
Andrew Parks
Hollman
Frank Pesce
Wiseguy
Dale Resteghini
Strip Club Patron (uncredited)
Peter O'Hara
Passerby (uncredited)
John Horton
FBI Director
Flint Beverage
Kings Court Cop (uncredited)
Sal Jenco
Mare Chiaro Bartender
James McCauley
FBI Agent
Walt MacPherson
Sheriff
Rocco Musacchia
Trafficante's Man
Randy Jurgensen
Wiseguy
Elle Alexander
Mob Girlfriend
Frankie Cee
Civilian (uncredited)
Ronnie Farer
Annette
Jim Lavin
Arresting FBI Officer (uncredited)
Elaine del Valle
Mob Girlfriend
Garry Pastore
Carmine Galante's Bodyguard (uncredited)
Teresa Giudice
Shocked Stripper (uncredited)
Gaetano LoGiudice
Wiseguy