Tom Hanks
Joe Fox
Jane Adams
Sydney Anne (uncredited)
Michael Badalucco
Charlie
Cara Seymour
Gillian Quinn
Dave Chappelle
Kevin Jackson
Meg Ryan
Kathleen Kelly
Parker Posey
Patricia Eden
Dabney Coleman
Nelson Fox
Greg Kinnear
Frank Navasky
Steve Zahn
George Pappas
John Randolph
Schulyer Fox
Reiko Aylesworth
Thanksgiving Guest
Bruce Jay Friedman
Vince Mancini
Heather Burns
Christina Plutzker
Veanne Cox
Miranda Margulies
Jean Stapleton
Birdie Conrad
Hallee Hirsh
Annabelle Fox
Deborah Rush
Veronica Cash
Katie Sagona
Young Kathleen Kelly
Katie Finneran
Maureen, the Nanny
Chris Messina
Fox Salesperson
Brick Mason
Man Letting Joe Fox in (uncredited)
Kathryn Meisle
Cecilia Kelly
Sara Ramirez
Rose, Zabars Cashier
Cecelia Antoinette
Restaurant Patron (uncredited)
Gideon Jacobs
Young Joe Fox (uncredited)
André Sogliuzzo
Waiter at Lalo
Scott Mullin
Male Runner (uncredited)
Jeffrey Scaperrotta
Matt Fox
Diane Sokolow
Zabars Shopper
Ronobir Lahiri
Man at Cafe Lalo
Elwood Edwards
Online 'You've Got Mail' Voice (voice) (uncredited)
Alfonso Gomez-Rejon
Party Guest (uncredited)
Howard Spiegel
Henry, Zabars Shopper
Anthony Welch
Business Executive (uncredited)
Enzo Angileri
Starbucks Customer
Mary A. Kelly
Fox Books Shopper
Dolores Sirianni
Mother of Twins
Bill McHugh
Party Guest
Maggie Murphy
Theater Patron
Logan Steinhardt
Kid in Bookstore (uncredited)
Nina Zoie Lam
T.V. Reporter
Julie Galdieri
Shopper
Richard Cohen
Starbucks Customer
Ann Fleuchaus
Sarah Mancini
Santiago Quinones
Decorator